Interferon regulatory factor 3-CL, an isoform of IRF3, antagonizes activity of IRF3
نویسندگان
چکیده
منابع مشابه
Membrane perturbation elicits an IRF3-dependent, interferon-independent antiviral response.
We previously found that enveloped virus binding and penetration are necessary to initiate an interferon-independent, IRF3-mediated antiviral response. To investigate whether membrane perturbations that accompany membrane fusion-dependent enveloped-virus entry are necessary and sufficient for antiviral-state induction, we utilized a reovirus fusion-associated small transmembrane (FAST) protein....
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TANK-binding kinase 1 (TBK1) is an important serine/threonine-protein kinase that mediates phosphorylation and nuclear translocation of IRF3, which contributes to induction of type I interferons (IFNs) in the innate antiviral response. In mammals, TBK1 spliced isoform negatively regulates the virus-triggered IFN-β signaling pathway by disrupting the interaction between retinoic acid-inducible g...
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ژورنال
عنوان ژورنال: Cellular & Molecular Immunology
سال: 2010
ISSN: 1672-7681,2042-0226
DOI: 10.1038/cmi.2010.55